| 產(chǎn)品編號(hào) | bs-18543R |
| 英文名稱 | TIP39 Rabbit pAb |
| 中文名稱 | 甲狀旁腺(激)素及類似物抗體 |
| 別 名 | BK445C9.6; DKFZP434B194; FLJ22086; HNtr1; NTR1; NTR1, S. cerevisiae, homolog of; OTTHUMP00000198650; OTTHUMP00000198850; OTTHUMP00000198851; OTTHUMP00000198852; Septin and tuftelin-interacting protein 1; Spp382; STIP; STIP-1; TFIP11; TFP11_HUMAN; TIP 39; 牙根管肽; 甲狀旁腺激素2; |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TIP39: 62-100/100 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Tuberoinfundibular peptide of 39 residues (TIP39) was initially identified as a neurotransmitter and agonist of the PTH2 receptor, which is expressed in the cardiovascular system. Accumulating evidence suggests that TIP39 may be the endogenous ligand of the parathyroid hormone 2 receptor. The vast majority of TIP39 containing neurons are localized in two regions, the subparafascicular area at the thalamic midbrain junction, and the medial paralemniscal nucleus in the rostral pons. In contrast to the restricted localization of TIP39 containing cell bodies, TIP39 containing fibers have a widespread distribution. Function: Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. Subunit: Ligand of high affinity for the PTH2 receptor (PTH2R). Subcellular Location: Secreted Tissue Specificity: Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart. Similarity: Belongs to the parathyroid hormone family. SWISS: O43460 Gene ID: 11191 Database links: Entrez Gene: 113091 Human Entrez Gene: 114640 Mouse SwissProt: Q96A98 Human SwissProt: Q91W27 Mouse Unigene: 339845 Human |
