| 產(chǎn)品編號 | IHC0416H |
| 英文名稱 | Human Complement C9 Ready-To-Use IHC Kit |
| 中文名稱 | 人補體C9即用型免疫組化試劑盒 |
| 別 名 | ARMD15; C9; C9D; complement C9 |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated. SWISS: P02748 Gene ID: 735 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human kidney tissue slide using IHC0416H (Human Complement C9 IHC Kit).
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