| 產(chǎn)品編號(hào) | IHC0429M |
| 英文名稱 | Mouse TARDBP Ready-To-Use IHC Kit |
| 中文名稱 | 小鼠Tar DNA 結(jié)合蛋白43即用型免疫組化試劑盒 |
| 別 名 | 1190002A23Rik; ALS10; C85084; TARDBP; TDP-43; TDP43; wu:fb77f02; wu:fc52g10 |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences. SWISS: Q13148 Gene ID: 23435 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded mouse cerebellum tissue slide using IHC0429M (Mouse TARDBP IHC Kit).
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