| 產(chǎn)品編號(hào) | IHC0443H |
| 英文名稱 | Human MtTF1 Ready-To-Use IHC Kit |
| 中文名稱 | 人線粒體轉(zhuǎn)錄因子1即用型免疫組化試劑盒 |
| 別 名 | AI661103; Hmgts; MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3; TFAM; tsHMG; MTDPS15 |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Mitochondrial transcription factor A (TFAM) is a crucial protein encoded by nuclear genes, but it is transported from the cytoplasm to mitochondria where it plays a key role in the maintenance and expression of mitochondrial DNA (mtDNA). It regulates the replication and transcription of mtDNA, ensuring the proper functioning of mitochondrial processes. Structurally, TFAM contains a molecular region known as the LC3 interacting region (LIR) motif, which allows it to bind to autophagy proteins such as LC3. This interaction is essential for the autolysosomal pathway, helping to eliminate leaked mtDNA and limit inflammation. TFAM levels vary across tissues, with notable effects on mitochondrial function; high levels can repress mtDNA expression in certain tissues, such as skeletal muscle, and contribute to deficiencies in oxidative phosphorylation (OXPHOS). Conversely, in other tissues like the heart, increased mtDNA copy number maintains a balanced TFAM-to-mtDNA ratio, preserving OXPHOS capacity. TFAM is integral to the packaging, stability, and replication of the mitochondrial genome, and disruptions in TFAM can have severe effects, including implications in neurodegeneration and other diseases related to mtDNA stress. SWISS: Q00059 Gene ID: 7019 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human esophagus tissue slide using IHC0443H (Human MtTF1 IHC Kit).
Immunohistochemical analysis of paraffin embedded human kidney tissue slide using IHC0443H (Human MtTF1 IHC Kit).
Immunohistochemical analysis of paraffin embedded human thyroid carcinoma tissue slide using IHC0443H (Human MtTF1 IHC Kit).
Immunohistochemical analysis of paraffin embedded human testis tissue slide using IHC0443H (Human MtTF1 IHC Kit).
Immunohistochemical analysis of paraffin embedded human lung cancer tissue slide using IHC0443H (Human MtTF1 IHC Kit).
|
